5-HTP Shown To Naturally Enhance Mood, Induce Calm, & Increase Rest

Boost your Mood with 5-HTP and Serotonin

Serotonin has been shown to be a key neurotransmitter linked to mood, happiness, and positive outlook. Combining the two raw building blocks of serotonin, L-tryptophan and 5-HTP, with a converting catalyst, Vitamin B6, New MOOD provides the nutrients to help the body become a serotonin-boosting powerhouse. Adding to the naturally relaxing effects of L-Tryptophan are a host of traditional anti-stress herbs designed to bring you into a state of peaceful calm. Magnesium is an essential mineral vital for muscle relaxation and Vitamin D3 which is increasingly deficient in our diets, has further been linked to positive mood benefits. Ideal for when you are under stress, anxious, or exhausted, New MOOD is also optimal for daily use.†

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Find your Nirvana

The Buddha described typical life as a state of suffering — the opposite of which he called Nirvana, or a state of pure bliss. Some of the things contributing to the Buddha's philosophy could be low levels of serotonin — potentially caused by inadequate nutrients or a lack of deep sleep. Another antagonist to happiness is stress. Stress creates cortisol which over time can wreak havoc on body chemistry. Niacin and magnesium are included in New MOOD along with a host of herbs with thousands of years of traditional use for helping the body to reduce stress and assist in a state of calm and relaxation. New MOOD is ideal before bed or any time you find yourself stressed out, down in the dumps, or a little too wired.†

“When my job requires me to adhere to a challenging and stressful schedule, I depend on New MOOD to relax and recover.”

Mehcad Brooks - Actor

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Serotonin: The natural way

Serotonin has been linked to positive mood and healthy emotional balance. It comes as no surprise therefore that the majority of prescription anti-depressants are focused on creating a surplus of serotonin, typically by inhibiting the re-uptake. New MOOD takes a different approach. The natural production of serotonin begins with the common amino acid L-Tryptophan. L-Tryptophan converts to 5-HTP which is the direct precursor of this essential neurotransmitter (5-HT). New MOOD contains both L-Tryptophan and 5-HTP, creating a time release effect that when combined with Vitamin B-6, assists the body in generating strong levels of natural serotonin.†

“I have a ton of energy all the time, and my mind is constantly going which is a problem sometimes when I go to bed. New MOOD helps calm my nerves so I can stay more focused.”

Melissa Molinaro - Triple Threat

The science of New MOOD

5-HTP is at the heart of this revolutionary formula, and this is no surprise as a groundbreaking published and peer-reviewed clinical study conducted by Dr. W. Poldinger confirmed the positive mood boosting effects of this nutrient.1 Valerian, another powerful herb, was similarly demonstrated to be effective in improving ability to fall asleep.2 The formula as a whole represents the culmination of the best herbs and nutrients available, each individually helping to contribute to overall peace, tranquility, and positive mood.†

“When I'm on set, we will work 16-hour days for weeks at a time. New MOOD is a real lifesaver.”

Javier Quintana - TV Producer

[1] Poldinger W, Calanchini B, Schwarz W: A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991, 24:53-81.
[2] Stevinson C, Ernst E: Valerian for insomnia: a systematic review of randomized clinical trials. Sleep Med 2000, 1:91-99.

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Natural ingredients

• 5-HTP: Direct precursor of the neurotransmitter serotonin, aids in positive mood.†
• L-Tryptophan: Found commonly in turkey, aids in restfulness and converts to 5-HTP.†
• Magnesium: Calming, anti-stress mineral helpful for muscular hydration.†
• Vitamin B-6: Vital for the conversion of 5-HTP to serotonin and myriad other reactions.†
• Niacin: Essential vasodilator, brings nutrient rich blood flow to the skin and brain.†
• Vitamin D-3: The "sunlight" vitamin, linked to overall health and positive mood.†
• Chamomile: The most popular relaxation herb in the world.†
• Valerian Root: A clinically investigated sleep inducing nutrient.†
• Lemon Balm: A mild traditional mood-enhancing herb that is part of the mint family.†
• Jujube: A traditional anti-stress and relaxation extract, also known as zyzyphus.†

New MOOD™ by Onnit™ Labs is a serotonin-boosting supplement aimed at elevating a positive affective state and promoting restful sleep. The New MOOD™ formula includes neurotransmitter precursors with the co-factor vitamin B6, catalyzing the synthesis of serotonin in the brain. Additionally, four natural extracts, with a long tradition of reducing stress and combating poor sleep, are paired with two essential vitamins and magnesium to promote a mental state of calmness and well-being.

The Role of Serotonin

The neurotransmitter serotonin has a well-described role in regulating mood states and cognition in the human brain. Insufficient serotonin activity is centrally related to the hypotheses of mood imbalance[source]. Historical use of pharmacological agents, such as the serotonin selective reuptake inhibitors (SSRIs) approved in the late 1970s, showed the effectiveness of elevating serotonin in the central nervous system. More recent methods of neuroimaging, such as positron emission tomography (PET) tracers, permit a noninvasive approach to measuring serotonergic activity. A recent study correlated positive and negative mood states to the relative amount of radiolabeled C11 5-HTP[source], highlighting the significance of 5-HTP to serotonin conversion in the regulation of emotion (Figure 1).

Alhough pharmacological agents targeting serotonin are effective at elevating mood, the multitude of side effects has prompted alternative methods of increasing serotonin levels in the brain. Since the 1980s, there has been considerable focus on serotonin precursors mitigating poor mood. Several clinical trials using the serotonin precursors 5-hydroxytrypophan (5-HTP) and tryptophan have produced strong evidence for the use of these bioactive compounds in elevating mood[source]. The inclusion of 5-HTP and tryptophan, combined with the co-factor vitamin B6 in the New MOOD™ formula, can help the body enhance the active production of serotonin within neuronal cells.

Serotonin Precursors Elevate Mood

Cells outside of the brain also produce and utilize serotonin, yet this peripheral serotonin cannot be used as neurotransmitter because of its inability to cross the blood-brain barrier. Instead L-tryptophan is ingested through diet and is enzymatically converted to 5-HTP with the help of vitamin B6. The synthesis of serotonin is regulated by the rate-limiting step of L-tryptophan to 5-HTP. In other words, supplementing the body with 5-HTP allows for a rapid conversion to serotonin production. Meanwhile, the inclusion of L-tryptophan permits a slower, more prolonged production of serotonin.

Several studies have tested the effectiveness of serotonin precursors in altering mood states. A Japanese study supplemented 100 patients with either 5-HTP or placebo and observed a significant improvement in mood in 69% of treated patients after two weeks [source]. A follow up study in Switzerland compared the effectiveness of 5-HTP supplementation to SSRIs in patients with poor mood. In a double-blind, multicenter study, both treatment groups showed near equal reduction in depressive characteristics by the end of six weeks[source]. The effective delivery of serotonin precursors and their efficacy remains a topic of investigation, yet the present clinical data that exists suggests 5-HTP and L-tryptophan supplementation can aid in promoting positive mood.

Magnesium Deficiency Linked to Low Serotonin

The lack of magnesium in most processed foods in the U.S. has made it difficult to maintain optimal levels of this important mineral[source]. The magnesium ion plays a crucial role in gating ion channels in neuronal cells and low magnesium concentration can result in neurological dysfunction[source]. This mechanism has led to the hypothesis that low levels of magnesium disrupt the adequate functioning of serotonergic neurons. Further studies have confirmed this idea by showing that SSRIs improve the action of magnesium within brain cells. Magnesium has successfully benefitted individuals with temperament imbalance and most notably patient with treatment-resistant mood issues[source]. Another study showed magnesium supplements to be useful for preventing test taking stress and elevating serotonin levels[source]. Magnesium supplements are regarded as highly effective against adverse mood states with few concerns for safety or toxicity.

Natural Extracts Round Out New MOOD™

Many natural herbs have a traditional use for decreasing anxiety and promoting restfulness. New MOOD™ includes chamomile, which in two recent double-blinded studies showed modest improvements in reducing overall anxiety and combating difficulty sleeping [source, source]. Valarian root has also been systematically reviewed and tested as useful agents for promoting restful sleep in subjects who report abnormal or fluctuating sleep patterns[source, source]. Lastly, lemon balm has been shown to have anti-stress effects through GABA mediated inhibition and is synergistic with valerian root extract[source]. Overall the inclusion of these natural extracts in the New MOOD™ are designed to significantly lower stress and can induce more restful sleep.

Finding Balance with New MOOD™

The ingredients in New MOOD™ have targeted the serotonin neurotransmitter system, which is a known regulator of positive mood and sleep onset. The serotonin precursors, 5-HTP and L-tryptophan, have been shown to help the body increase the production of serotonin within the brain and serve as a natural alternative to other mood boosting solutions. The co-factor vitamin B6 strengthens the formula by catalyzing the conversion of 5-HTP to serotonin. Finally, New MOOD™ includes magnesium, an essential mineral for proper neurological functioning, and four natural extracts known to promote healthy sleep and mitigate anxiety. Each component in New MOOD™ has undergone a battery of scientific testing, and subsequent peer-reviewed studies have indicated effectiveness in respective analyses. New MOOD™ is a valuable supplement for those aiming to achieve a positive emotional state and maintain a pattern of healthy sleep.

Reference

• 4.)Sano I: [Treatment of endogenous depression with L-hydroxy-tryptophan (L-5-HTP)]. Nihon Rinsho 1973, 31:185-190.

Ingredients

L-Tryptophan

L-Tryptophan is an essential amino acid found naturally occurring in turkey and other proteins. It is the building block for 5-HTP, the direct precursor of Serotonin, however it is also available to convert to Melatonin, aiding in restfulness and sleep.†

5-HTP

The direct precursor and metabolic intermediate of serotonin, 5-HTP is the best nutrient to restore and enhance the body' natural supply of Serotonin.†

Magnesium (Chelate)- 150 mg

Magnesium is needed for hundreds of your body's basic functions, including regulating your heart, blood pressure and nervous system. Promoting a sense of muscular and physical calm, magnesium is commonly used to combat stress and restlessness.†

Vitamin D3

Ever feel happier after being in the sun? Vitamin D3 is vital to maintaining proper blood levels of calcium and phosphorous, among many other important functions. Recent evidence suggests that it is difficult for the body to maintain optimum levels of Vitamin D through sunlight and nutrition alone.†

Chamomile (1.2% Apigenin)

Another ancient and widely used herb, the chamomile flower has long been sought for its calming, anti-stress properties. Our concentrated formula is one of the strongest available on the market, and will provide effects 10x stronger than a cup of warm chamomile tea.

Vitamin B6

Pyridoxine (Vitamin B6) is one of the body's busiest vitamins, involved in an estimated 101 chemical reactions. One of its primary tasks is to aid in the manufacturing of amino acids and neurotransmitters, including serotonin.†

Niacin

Vitamin B3 is one of the most effective natural vasodilators available. Opening up capillaries and blood vessels, Niacin allows the restorative power of oxygenated blood to cleanse and detoxify the system. †

Valerian Root

Valerian root, scientifically known as valeriana officinalis, is a hardy, perennial flowering plant that is native to Europe and parts of Asia. Valerian root has been used since the classical era of ancient Greece as a treatment of restlessness. New clinical data supports its effectiveness in helping the body sleep restfully.†

Lemon Balm (4:1 Concentration)

Lemon balm is a perennial herb in the mint family native to southern Europe and the Mediterranean regions. Studies have shown lemon balm to be helpful to the body in maintaining positive mood.

Jujube Seed Extract

The Jujube tree has its origins in China but has rapidly been cultivated throughout the world due to the prized properties of both the fruit and the seed. The seed in particular is widely used as an herbal treatment for restlessness. Three specific compounds found within the seeds have been researched in regards of this effect: flavonoids, saponins, and polysaccharides.†

Products including Alpha BRAIN, New MOOD, Shroom TECH Sport, and Shroom TECH Immune have a shelf life of two years from the manufacturer date found on the bottle.