N,N-Dimethyltryptamine (DMT or N,N-DMT) is a psychedelic compound of the tryptamine family. Its presence is widespread throughout the plant kingdom. DMT occurs in trace amounts in mammals, including humans, where it putatively functions as a trace amine neurotransmitter/neuromodulator. It is originally derived from the essential amino acid tryptophan and ultimately produced by the enzyme INMT during normal metabolism. The significance of its widespread natural presence remains undetermined. Structurally, DMT is analogous to the neurotransmitter serotonin (5-HT), the hormone melatonin, and other psychedelic tryptamines, such as 5-MeO-DMT, bufotenin, psilocin and psilocybin.
OnsetWhen smoked, DMT generally reaches full effects within 10-60 seconds of inhalation.
DurationThe primary effects of N,N-DMT last approximately 5-20 minutes when smoked. For many people there is an additional period of time (1-2 hours) before fully returning to baseline. Some people find DMT experiences difficult to integrate and experience unsettling thoughts and feelings for days after use.
Visual EffectsBrightly colored, high-res detail, geometric, organic, overlapping, and somewhat kaleidoscopic; may be fast or slow moving, but a sense of motion is often present. Depictions of ayahuasca visions and DMT visions have been featured in the recent films Renegade (2004) and Enter The Void (2009).
One of the primary physical problems encountered with smoked or vaporized N,N-DMT is the harsh nature of the smoke or vapor, which can cause throat and lung irritation. Integration of the smoked/vaporized DMT experience can also cause difficulties for some individuals, especially at higher doses. Challenging integration periods can lead to anxiety, trouble focusing on daily tasks, preoccupation with the experience, difficulty sleeping, etc. Generally these effects dissipate on their own over the course of a few days, but there have been reports of persisting problems.
ContraindicationsThe effects of smoked N,N-DMT are dramatically increased if used by individuals currently taking MAOIs. MAOI drugs include the prescription antidepressants Nardil (phenelzine), Parnate (tranylcypromine), Marplan (isocarboxazid), Eldepryl (l-deprenyl), and Aurorex or Manerix (moclobemide), as well as the harmala alkaloids present in Banisteriopsis caapi (ayahuasca) and Peganum harmala (Syrian rue). Check with your doctor if you are not sure whether your medication is a MAOI.
Do not stand up. Do not operate heavy machinery. Do Not Drive.
Individuals currently in the midst of emotional or psychological upheaval in their everyday lives should be careful about choosing to use psychedelics such as N,N-DMT as they can trigger even more difficulty.
Individuals with a family history of schizophrenia or early onset mental illness should be extremely careful because psychedelics have been known to trigger latent psychological and mental problems.
Addiction PotentialDMT is neither physically addicting nor likely to cause psychological dependance. As with most substances, some people will use it more frequently than they are comfortable with. There may be a short period of tolerance after DMT use. However, Strassman et al. found in a tolerance study of DMT that four successive high-dose IV injections of DMT administered at 30-minute intervals produced no noticeable tolerance effect.
intense open eye visuals and kaleidescopic patterning
powerful "rushing" of sensation
radical perspective shifting
profound life-changing spiritual experiences
NEUTRALchange in perception of time
auditory hallucinations / sound distortions (buzzing)
colorshifting (for example red green and gold coloring to the whole world)
hard on the lungs to smoke
slight stomach discomfort
difficulty integrating experiences
fast onset and intensity can lead to problems if not prepared (dropped pipe, knocking things over, falling)
The Spirit Molecule
DMT has been an active part of almost all life forms for quite sometime. Is there a reason for this? Could it be the key to unlocking the mysteries of our consciousness and better understanding our own minds? Perhaps it will explain why we dream at night or out-of-body experiences. Or is it just another street drug that makes you "hallucinate" and should be outlawed? What do you think?
- Häfelinger, G.; Nimtz, M.; Horstmann, V.; Benz, T. (1999). "Untersuchungen zur Trifluoracetylierung der Methylderivate von Tryptamin und Serotonin mit verschiedenen Derivatisierungsreagentien: Synthesen, Spektroskopie sowie analytische Trennungen mittels Kapillar-GC" [Trifluoracetylation of methylated derivatives of tryptamine and serotonin by different reagents: synthesis, spectroscopic characterizations, and separations by capillary-gas-chromatography]. Zeitschrift für Naturforschung B 54 (3): 397–414
- Corothie, E; Nakano, T (1969). "Constituents of the bark of Virola sebifera". Planta Medica 17 (2): 184–188.
- Ott, Jonathan (1994). Ayahuasca Analogues: Pangæan Entheogens (1st ed.). Kennewick, WA, USA: Natural Products. pp. 81–3.
- Shulgin, Alexander; Shulgin, Ann (1997). "DMT is Everywhere". TiHKAL: The Continuation (1st ed.). Berkeley, CA, USA: Transform Press. pp. 247–84.
- Burchett, Scott A.; Hicks, T. Philip (August 2006). "The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain" (PDF). Progress in Neurobiology 79 (5–6): 223–46.
- Barker S.A., Monti J.A., Christian S.T. (1981). "N, N-dimethyltryptamine: an endogenous hallucinogen". International Review of Neurobiology. International Review of Neurobiology 22: 83–110.
- Salak, Kira. "Hell and back". National Geographic Adventure
- "Erowid DMT (Dimethyltryptamine) Vault". Erowid.org.
- McKenna, Dennis J.; Towers, G.H.N.; Abbott, F. (April 1984). "Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and β-carboline constituents of ayahuasca". Journal of Ethnopharmacology 10 (2): 195–223.