Explore Your Brain's True Potential!

Neurosurgeon Martin Lazar, MD, FACS discusses the benefits that Alpha BRAIN by Onnit Labs has for cognition, mental capacity, memory enhancement, and alertness.

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Natural ingredients

• Alpha GPC: Raw source of acetylcholine, associated with sharpness, mental speed.✝
• Huperzin A: Acetylcholinesterase inhibitor, extracted from club moss.✝
• Vinpocetine: Helps bring oxygen and nutrients to the brain via vasodilation.✝
• AC-11 : Powerful DNA repair antioxidant.✝
• Phosphatidylserine: Essential lipid compound highly abundant within brain cell membranes.✝
• Bacopa: Traditional Ayurvedic brain-enhancing nutrient.✝
• L-tyrosine: Amino acid important to the production of Dopamine.✝
• L-Theanine: Amino acid with chemical similarities to GABA.✝
• Oat Straw (20:1): Natural anti-stress nutrient, helps balance formula and create calm focus.✝
• Vitamin B-6: Catalyst in effective utilization of many nutrients.✝ 

Complete balanced nootropic

The idea behind Alpha BRAIN was to create a fully-balanced nootropic. Our Alpha GPC and Huperzia Serrata contain nutrients that help your body turn up acetylcholine levels full throttle while other ingredients assist in elevating neurological components vital to remaining calm, focused, and mentally driven. Our Vinpocetine can help the body deliver oxygen and nutrients to the brain, and the combination of neuro-specific antioxidants, led by our proprietary AC-11®, assists your system in clearing away mental fog and free radicals. The result for our thousands of satisfied customers is an extraordinary combination of lucid dreams, mental drive, focus, and mental acuity.✝

Actualizing your Alpha BRAIN

What is it that separates the great minds from the good minds? Raw intelligence is a factor; but what else? Is it the ability to quickly access information? Is it the ability to efficiently store learned information? Is it the ability to induce connections between seemingly unrelated events? Is it the ability to stay focused and determined? The knack for staying calm in tense situations and driven towards your goals? If that is what makes a great mind, then Alpha BRAIN is the ideal brain food. Containing nutrients designed to help the body elevate levels of major neurotransmitters, Alpha BRAIN can help you to actualize your mind's true potential.✝

Create through the dream state

A study done on acetylcholine boosting drugs had an interesting side effect: vivid, and often lucid dreams. This led researchers to study the mechanism further, and what they found was something that sleep experts had known all along: acetylcholine is the neurotransmitter responsible for regulating REM sleep. The more acetylcholine available, the more persistent and broad the REM cycles for the subjects studied. Alpha BRAIN is designed to be of the most potent acetylcholine-enhancing nutrient based supplements available, and the results on the dream state go beyond expectations. Where will you travel? What will you create? Its all up to you.✝

AC-11® — Rainforest super herb

The Amazonian rainforest is the home of cat's claw, revered by traditional cultures for its anti-inflammatory, antioxidant, and immune-boosting properties. After years of research, the creators and founders of AC-11 developed a hot water extraction process based on a proprietary molecular sieving technology, creating AC-11 — The Rainforest Super Herb. The results are a compound shown in clinical study to repair DNA. It is placed in the Alpha BRAIN formula to help the body improve mental drive and eliminate mental fog. AC-11 is the perfect joining of the rainforest's secrets with the miracle of today's advancements in phytonutrient science.✝

Get in the Alpha Zone

Every athlete knows what it feels like to be in the zone. Your focus is sharp, your anticipation is quick, and you execute effortlessly. An entire field of sports psychology has grown up around how to prepare the athlete’s mind to get into this state. Certainly emotional and psychological factors play a role, but what if it is something to do with your actual brain chemistry? What if enhanced acetylcholine not only increases your mental focus, but your physical focus as well? What if enhanced dopamine levels improve athletic dexterity instead of just general locomotion? What if certain herbs and nutrients can help keep you cool and collected during the trials and tribulations of competition?

Reports from the thousands of Alpha BRAIN users points to one thing: Yes. There are golfers scoring lower than they have in years. There are tennis players beating people they never have before. There are grapplers submitting people way above their belt. There are strikers recognizing targets faster than they ever have. Could this all be coincidence? It’s possible… But for those who experience the effects, they can feel it happening. The Alpha BRAIN athletic phenomonenon is real. Take a look at some of our pro athletes, and read their testimonials. Give it a try yourself, and let us hear your amazing story.

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Research

Alpha BRAIN, the flagship cognitive enhancing supplement from Onnit Labs, contains a serving of nine natural, well-researched compounds to create an effective and balanced nootropic. Alpha BRAIN® aims to elevate focus and mental clarity to help the brain achieve improved cognitive functioning. The ingredients in Alpha BRAIN are centered on three aspects of enhanced cognition: elevating levels of endogenous neurotransmitters, providing anti-stress compounds, and promoting long-term neuroprotection.

Boosting Neurotransmitters

The human brain is comprised of over 10 billion communicating cells, known as neurons, making over 60 trillion synaptic connections[1]. Neurotransmitters are the chemical messengers that embody the brain’s currency of communication. The highly coordinated processes of production and release determine the relative strengths or weaknesses between neighboring neurons. These connections give rise to complex neural circuits, which underlie the apparent phenomena of human cognition.

It is well known that adequate functioning of neurotransmitter synthesis and release is essential to maintain a healthy cognitive state[2]. Self-perceived states, such as attention, mood, focus, and awareness are highly dependent on the relative levels of neurotransmitter production. Alpha BRAIN aims to elevate the levels of the neurological production of neurotransmitters by providing an abundance of biological neurotransmitter precursors. Specifically, huperzia serrata and aGPC are targeted at increasing acetylcholine function, an essential component for learning and memory[3, 4]. L-theanine, a compound isolated from green tea, has been shown to mimic the important inhibitory effects of GABA neurotransmission, mediating a calm and focus mental state[5]. L-tyrosine is a key intermediate in the biosynthesis of the neurotransmitters dopamine, epinephrine, and norepinephrine with documented mood elevating properties[6]. Taken together, the ingredients in the Alpha BRAIN formula provide a strong foundation to enhance the body’s endogenous production and maintenance of key neurotransmitters.

Mitigating Stress

Prolonged environmental stress results in a physiological response that can be harmful to overall health and neurological function. Alpha BRAIN includes a combination of natural anti-stress compounds that have been shown to buffer the brain’s response to stress and provide an overall calming effect. Under the license from Optigenex, Alpha BRAIN is the only nootropic to include AC-11®, a potent extract from Uncaria tomentosa found in the Amazon rainforest and used for hundreds of years as an alimentary herb. AC-11® has independently been proven to promote DNA repair following environmental stress and has documented cognitive benefits[7]. Alpha BRAIN also includes highly concentrated oat straw (Avena sativa), an alleviator of exhaustion and neurological pain that has been shown to have a positive impact on cognitive performance in healthy subjects[8]. Lastly, Alpha BRAIN contains phosphatidylserine, a phospholipid cell component known to possess ergogenic properties and promote stress tolerance in high performance athletes[9]. Alpha BRAIN aims to decrease our levels of endogenous stress while providing the tools to handle demanding situations, allowing a clear and focused mind.

Targeting Neurological Antioxidants

Oxidative stress, also known as free radical damage, has been implicated in a number of neurological challenges and age-related conditions[10]. Alpha BRAIN includes the highest quality anti-oxidative compounds that have been shown to be beneficial to cognitive function. Pterostilbene, a recently discovered compound isolated from blueberries, has been shown to provide neuroprotection against free radicals[11]. Bacopa Monnieri has been used for centuries in the traditional Ayurvedic medical system of India to improve memory and longevity, possessing both antioxidant and aptogenic effects[12]. Research on Bacopa has shown significant memory improvements and protection again the deposit of harmful neurotoxic molecules[13]. Finally, the inclusion of vinpocetine, a semi-synthetic derivative of the periwinkle plant, promotes blood flow to the brain and possesses potent anti-oxidant properties[14]. These three potent antioxidants are essential to maintaining a healthy and functional nervous system.

Alpha BRAIN Delivers

The Alpha BRAIN formula contains highly effective ingredients that are either cutting edge or have historical use. This combination aims to potentiate the best cognitive performance while maintaining mental clarity and long-term neurological health benefits. With a double-blind clinical study currently underway, we hope to be able to provide additional data on the efficacy of Alpha BRAIN as a formula by Q3 2013.

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Reference

1. Brancucci A: Neural correlates of cognitive ability. J Neurosci Res.
2. Crupi R, Marino A, Cuzzocrea S: New therapeutic strategy for mood disorders. Curr Med Chem, 18:4284-4298.
3. Orhan IE, Orhan G, Gurkas E: An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini Rev Med Chem, 11:836-842.
4. Amenta F, Tayebati SK, Vitali D, Di Tullio MA: Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission. Mech Aging Dev 2006,127:173-179.
5. Song J, Xu H, Liu F, Feng L: Tea and cognitive health in late life: current evidence and future directions. J Nutr Health Aging, 16:31-34.
6. Mouret J, Lemoine P, Minuit MP, Robelin N: [L-tyrosine cures, immediate and long term, dopamine-dependent depressions. Clinical and polygraphic studies]. C R Acad Sci III 1988, 306:93-98.
7. Emanuel P, Scheinfeld N: A review of DNA repair and possible DNA-repair adjuvants and selected natural anti-oxidants.Dermatol Online J 2007, 13:10.
8. Dimpfel W, Storni C, Verbruggen M: Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects. J Altern Complement Med, 17:427-434.
9. Starks MA, Starks SL, Kingsley M, Purpura M, Jager R: The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr 2008, 5:11.
10. Ghosh N, Ghosh R, Mandal SC: Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease. Free Radic Res, 45:888-905.
11. Chang J, Rimando A, Pallas M, Camins A, Porquet D, Reeves J, Shukitt-Hale B, Smith MA, Joseph JA, Casadesus G: Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiol Aging.
12. Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ: Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res 2008, 22:1629-1634.
13. Shinomol GK, Bharath MM, Muralidhara: Neuromodulatory Propensity of Bacopa monnieri Leaf Extract Against 3-Nitropropionic Acid-Induced Oxidative Stress: In Vitro and In Vivo Evidences. Neurotox Res.
14. Patyar S, Prakash A, Modi M, Medhi B: Role of vinpocetine in cerebrovascular diseases. Pharmacol Rep, 63:618-628.

✝ - This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease